Relationship between Low Density Lipoprotein and High Density Lipoprotein in Diabetes Mellitus
Ikpe Vitalis; Alex Idoko & Esotu Amarachi
Department of Biochemistry, Faculty of Natural Sciences
Caritas University, Amorji-Nike Enugu
Email: vitalis.ikpe@yahoo.com
ABSTRACT
Diabetes mellitus is a group of metabolic diseases characterized by abnormally high level of glucose in the blood. A lipoprotein is a biochemical assembly whose purpose is to transport hydrophobic lipid molecules
in water as in blood or extracellular fluid. Fasting venous blood samples were collected from 60 diabetic patients (30 males and 30 females, aged 30 – 50 years) and 60 non-diabetic persons (30 males and 30 females,
aged 30-50 years) into fluoride and plain tubes. The fluoride samples were estimated for fasting blood glucose (FBG) with glucose oxidase method while the serum samples were assayed for total cholestorol
(TC), low density lipoprotein (LDL), high density lipoprotein (HDL) and triglyceride (TG) spectrophotometrically. Total serum cholesterol increased from a control value of 4.8±0.9 mmol/L to 8.6±3.7 mmol/L, LDL increased from 1.38±1.02mmol/L to 4.7±2.9 mmol/L, HDL increased from 0.7±0.3mmol/L to 2.1±1.4mmol/L and triglyceride from 0.79±0.31mmol/L to 1.8± 0.99mml/L. The ratio of LDL-to HDL concentration was 2.2:1; HDL: TC ratio 1:2.5; LDL: TC ratio1:1. All these are statistically significant
(P<0.05) and unacceptable in the management and control of diabetes.
Key words: Cholesterol, HDL, LDL, ratio, relationship.
