Category Archives: International Journal of Medical Science and Applied Biosciences, volume 9, number 2, 2024

  • March 22, 2025
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Anti-Trypanosomal Efficacy of Garcinia kola Aqueous Seed Extract as an Alternative Remedy in Treatment of Trypanosomiaisis Disease

Category : International Journal of Medical Science and Applied Biosciences, volume 9, number 2, 2024

Moses Oluwaseun Abiodun, Anthony Obinna Ekesiobi & Leonard Chikwado Onyenweife

ABSTRACT

This study investigated trypanosomal activity, haematological and lipid profile effects of Garcinia kola aqueous seed extract and compared with Berenil (Diaminizene aceturate) drug in treatment of typanosomiasis induced Wistar rat.  The extract was obtained through Maceration method with distilled water, In vitro activity of the extract and Berenil drug was determined using rapid matching techniques at 3 hours post incubation period with different doses of the extract and 3.5mg of Berenil drug. In vivo study was done using 62 Wister rats, divided into 10 groups. Group A (normal control): non infected and non -treated, Group (B-H) were infected by intra peritoneal inoculation of 1mL of parasitized blood containing 1.0´105/ml of T. brucei gambianse parasites and treated with different doses of Garcinia kola seed extract, 200 – 1400mg, Group I: infected and treated with standard drug dose, Group J: infected and non- treated (Pathological control). The treatment lasted for 21 days at 3 days interval.  Hematological and lipid profile effects were determined by colorimetric method. Data were analyzed statistically using Anova at 0.01 significant differences. Various hematological and lipid profile effects were observed in all the extract treated and control groups. Garcinia kola seed extract exhibited trypanosostatic at dose of <400mg and trypanocidal activity at doses > 400mg in both in vitro and in vivo, compared with trypanocidal activity of standard Berenil drug dose. Garcinia kola seed extract produced moderate side effect on haematological and lipids profile parameters of wistar rat at doses <400mg in the extract treated groups when compared with Berenil drug which produced higher toxicity effect on heamatological and lipid profile parameters at standard dose. This study revealed that Garcinia kola aqueous seed extract may be used to design drug for the treatment of trypanosomiasis at lower concentration therefore, the use of Berenil drug in human and animal treatment should be discontinued.

Keywords: Trypanosomiasis, Trypanosostatic, Wister rat,Berenil, Garcinia kola.  

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  • March 22, 2025
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Social Media Usage and the Development of Eating Disorders among Secondary School Adolescents in Ikeja, Lagos

Category : International Journal of Medical Science and Applied Biosciences, volume 9, number 2, 2024

Ajuzie Nnenna Choice1, Ogun Ireti B1, Ogbonnaya Faith Chidiebube2, Ukangwa Ngozi Angela2, Omotoye Ayodeji A1, Awoyinka Rachael I3, Emmanuel Godspresence C.

ABSTRACT

Eating disorders has been argued and characterized to been more prevalent in “developed” countries because of their beauty standard emphasis on thinness, it has been proposed that these “developed” countries with a higher prevalence of eating disorders shape developing countries into the development of eating disorders. The main objective of this research is to assess social media usage and the development of eating disorders among secondary school adolescents in Ikeja, Lagos using a cross- sectional study design and 232 respondents were selected for the study. Majority of the respondents (69.0%) were female and 31.0% were male of respondents. Less than average of the respondents (34.1%) were 15 years of age, while 4.7% were 18 years of age. More than average of the respondents (51.7%) Public Secondary School while the least percentage (48.3%) were in Private Secondary School. Majority of the respondents had normal Body Mass Index (70.3%), 20.3% were overweight, 9.5% obese and 0.4% underweight. Almost all the respondents (93.5%) use social media platforms above 30mins and 6.5% used social media platforms below 30mins while more than quarter of the respondents use Whatsapp (46.6%), Tiktok (27.2%) and Snapchat (28.9%) 5 or more times a day. 54 respondents (23.3%) scored positive (scored ≥ 20) on the EAT-26 thus representing the prevalence rate of eating disorder. There is significant relationship between social media usage and awareness of the calorie content of the food (p=0.01).

Key words= Eating Disorders, Adolescents, social media

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  • March 22, 2025
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Effects of Moroccan Watermelon Mosaic Virus (MWMV) on Growth, Some Elemental and Phytochemical Composition of the Leaf of Cucumeropsis edulis Naudin

Category : International Journal of Medical Science and Applied Biosciences, volume 9, number 2, 2024

Akpainyang, N. U.

ABSTRACT

Effects of Moroccan watermelon mosaic virus (MWMV) on Growth, Some Elemental and Phytochemical Composition of the Leaf of Cucumeropsis edulis Naudin were carried out. Test plants arranged in complete randomized designed were mechanically inoculated at 8 days except the control. Two months post inoculation, infected and healthy plants were harvested and studied for growth parameters using graphical method, weighing and linear measurements. The elemental contents of both infected and uninfected plants were evaluated using standard methods proposed by Association of Official Analytical Chemists. Phytochemical tests were performed on the plant extracts following standard procedures. The results showed that MWMV caused significant reductions (P<0.05) in all the growth parameters of Cucumeropsis edulis with mean shoot height and dry leaf weight being 52.82 ± 6.15 cm and 0.40 ± 0.31 g in infected sample compared to the corresponding healthy values of 75.00 ± 13.24 cm and 1.23 ± 1.00 g obtained for the control. All the elemental contents of MWMV – infected plant were significantly (P<0.05) reduced with zinc having the least mean value of 0.08 ± 0.21 mg/100 g while uninfected sample had 1.83 ± 0.00 mg/100 g. The phytochemical results of the crude extracts of C. edulis revealed the presence of alkaloid, flavonoid, saponin, tannin and terpene, all in varying concentrations in both the infected and healthy plant samples. There is need to control the spread of this virus through phytosanitational measure, use of resistant variety and effective quarantine services. This will provide food security and poverty alleviation.

Keywords:     Cucumeropsis edulis, Virus, Growth, Elemental and Phytochemical Composition.

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