Histological Effects of Ciprofloxacin on the Cytoarchiture of the Testes of Adult male Wistar Rats
E.O. Nweke’, F.C. Akpuaka², T. M Nweke’, C. O. Elemuo’
‘Department of Anatomy, Faculty of Basic Medical Sciences, Chukwuemeka Odomegwu Ojukwu University Uli,
Anambra State, Nigeria
²Department of Anatomy, Faculty of Basic Medical Sciences,
Abia State University, Uturu, Abia State, Nigeria
Email: nwekeelizabeth@yahoo.com
ABSTRACT
Ciprofloxacin is an antibiotic used for the treatment of a number of bacterial infections. Several studies have shown that ciprofloxacin may impair testicular functions of male wistar rat which led to the study of its effects on the testes. Twenty (20) male wistar rats (140.52± 11.25) were divided into four groups (n= 5); control (food and water ad libitium) and experimental groups (group B received 6.25mg/kg), (group C received 12.5mg/kg), and (group D received 25.0mg/kg) of ciprofloxacin, for forty (40) days respectively through orogastric tube. 24hours after the last administration for each group, the rats were anesthetized using ignasia method. The histological result (H&E) revealed incomplete maturation of spermatozoa, widening of the interstitial spaces, loss of interstitial leydig cells and testicular atrophy of the tested groups compared to their control group.
Keywords: Ciprofloxacin, antibiotics, testes, wistar rats
