Comparative Neurobehavioural Effect of Vigna unguiculata decrease Anxiety Related Behaviour in Swiss White Mice
Aduema, W., 1 Wariso, A.C2 Agbai, J.U.3
1 Department of Human Physiology, Gregory University, Uturu, Abia State
2 Department of Human Physiology, Abia State University, Uturu, Nigeria
3 Department of Human Anatomy, Abia State University, Uturu, Nigeria
Email:Wadioniaduema@gmail.com.
Corresponding Author: Aduema, W.
ABSTRACT
The effects of long term administration of Vigna unguiculata on anxiety related behavior in mice was studied. A total of 40 Swiss mice (male &female) were used for the experiment. They were randomly assigned into four groups (Control, Cooked beans, Uncooked beans and Serotonin precursor group) containing ten (10) mice each for the tests on neurobehaviour. Group 1 served as the control and was fed normal rodent chow only. Group II and Group III were fed (50% w/w) cooked and uncooked beans diet while Group IV was placed on serotonin precursor (5-HTP) diet (0.2mg/50g) respectively and clean drinking water ad libitum for 30 days. The light/dark transition box was used to access anxiety and fear related behavior. The group treated with cooked and uncooked beans had lower anxiety related activity compared to control, as seen in light chamber duration and grooming activities, etc .In conclusion, long term administration of Vigna unguiculata decreases anxiety and fear related activities in mice.
