The Effect of Garcinia kola (Bitter Kola) on Testosterone and the Histology of the Testes in male Albino Wistar Rats
1S.I Ovuakporaye, 2E.I.Odokuma
1Department of Human Physiology, Delta State University, P.M.B 001, Abraka, Nigeria
2Department of Anatomy and cell biology, Delta State University, P.M.B 001, Abraka, Nigeria
Email: simonovuakpo2006@yahoo.com
ABSTRACT
The study determined the effect of Garcina kola on testosterone and the histology of the testes in male albino wistarrats. Fifteen (15) male rats of the Wistar strain weighing 115g-220g were divided into groups of 3 (control, low dose, high dose) consisting of 5 male rats in each of the 3 groups to determine the effects of Garciniakola extract on testosterone. The control group was given only water and rat feed while the experimental groups of low dose and high dose were administered 5g/kg and 10g/kg respectively per body weight for a period of 28 days. The rats were sacrificed and testosterone from the blood in these 3 groups, were studied. Statistical analyses of data were determined by one way analysis of variance (ANOVA) followed by Post-hoc Turkey’s test. It was observed that the hormone testosterone from group 2 with values of 0.50 ±0.15 recorded a significant increase in testosterone when compared to group 1 (control)with values 0.29 ± 0.08,while group 3 with values 0.23 ± 0.08 recorded no significant changes in testosterone when compared with group 1 (control).
Keywords: Garcina kola, testosterone, histology of the testis, wistar rats
