DETERMINATION OF QUALITY DETERIORATION OF HYPENTENSIVE DRUG USING PHYSICAL PARAMETERS
Okon P. Akpan, Udeme U. Inyang, Akpan, E. Friday & Blessing I. Etim
Department of Science Technology
Akwa Ibom State Polytechnic Ikot Osurua, Ikot Ekpene
Email: apostleop5family@yahoo.com
Corresponding authors: Okon P. Akpan
ABSTRACT
The electrical conductivity and pH of expired and non-expired hypertensive drugs were investigated. Two samples each of the expired and non-expired drugs were examined using conductivity meter (Kalinipkan) and pH meter (Corning 425). Out of the two samples measured, the non-expired Exforge HCT was observed to have the highest conductivity value of 620.00 µS/cm and expired Twynsta with the lowest conductivity value of 410.00 µS/cm. The high conductivity drug shows its measure of ionic concentration and activity. Also, the expired Exforge HCT had the highest pH of 7.25 and non-expired Twynsta had the lowest pH of 7.10. The measured pH value are not too far from the pH of a normal human biological system which lies in the range of 7.30 – 7.45. The result of this work shows that the pH values of the expired drugs are higher than those of the non-expired drugs. Similarly, the conductivity value of the non-expired drugs are higher than those of expired drugs; hence the conductivity and pH parameters can be used to characterized and monitor the quality of hypertensive drugs with the view of detecting quality deterioration and adulteration of the drugs.
Keywords: Electrical conductivity, pH, expired drugs, non- expired drugs.
